frank100 wrote:
hold on........hmmm.....
gosh......marfan?
not sure
AND the aswer is D, not because it is very effective on prevention, only because is the only preventive measure you have in the options...the rest of the options sound like an already ill patient. when B, C, D are present you already are sick. (A) havenīt proven to decrease mortality in any tumor...so elimination!!! E is a better guess.
MEN II a is AD and due to mutation in RET gene.Testing DNA has 100% sensitivity and specificity and this syndrome can be detected in the family long before appearance of neoplasias.
Calcitonin level in a proband can be used as screening but once it is diagnosed then rest of family should undergo for RET gene analysis because being AD disease its recurrence rate is 50%.
Other use of Calcitonine is post-operative monitoring as CEA is used post-operatively in Ca Colon.
What do others friends say ??
GL
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| frank100
Forum Guru
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RET gene, is positive in 70% of the cases...low sensitivity
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| Sea_gull
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frank100 wrote:
RET gene, is positive in 70% of the cases...low sensitivity
Frank
Are you sure ?????????.
- Cecil says that Ret gene analysis has replaced Cacitonin assay which has many false positive and false negative results.
- Intepretation of diagnostic tests by Wallach page 698 says that RET gene analysis ahs 100% senstitivity and specificity to detect Carriers
- What is better ? To detect carriers(Gene mutation) before disease manifestation or detect Patients(Medullar thyroid carcinoma) when disease has appeared ??
GL
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