Prep4USMLE Forum » USMLE Step 2 CK Forum » Ob-Gyn Forum |   estrogenis in DUB

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study_ing Forum Fanatic Topics: 180 Posts: 2,511	09/02/06 - 09:05 AM             #1 i know that anovulation cozing unapposed estrogen cozes menorrhagia. yet in the treatment of un controlled bleeding iv estrogens are used..Y so? Edited by study_ing on 09/02/06 - 03:15 PM ___________________ If you yourself are at peace, then there is at least some peace in the world.
study_ing Forum Fanatic Topics: 180 Posts: 2,511	09/02/06 - 03:14 PM             #2 wasnt it the estrogen excess without the progesterone causing the endometrium to overgrow its blood supply and hence bleed? ___________________ If you yourself are at peace, then there is at least some peace in the world.
study_ing Forum Fanatic Topics: 180 Posts: 2,511	09/02/06 - 03:16 PM             #3 Prolonged uterine bleeding suggests the epithelial lining of the cavity has become denuded over time. In this setting, a progestin is unlikely to control bleeding. Estrogen alone will induce return to normal endometrial growth rapidly. Hemorrhagic uterine bleeding requires high-dose estrogen therapy. If bleeding is not controlled within 12-24 hours, a D&C is indicated. ___________________ If you yourself are at peace, then there is at least some peace in the world.
juanma0 Forum Senior Topics: 10 Posts: 146	09/02/06 - 09:14 PM             #4 This is what I think: Low dose estrogen (or pulsatile) = physiological High dose = negative feedback Could that answer ur question.
study_ing Forum Fanatic Topics: 180 Posts: 2,511	09/04/06 - 09:47 AM             #5 well..duznt high dose estrogen have positive feedback properties important for the hormonal changes responsible for ovulation... what i deduced was that prolonged bleeding--> epitjelium denuded--more bleeding.. remember progesterone axn requires priming by estrogen too. here the hi dose estrogen restores normal epithelial growth rapidly ___________________ If you yourself are at peace, then there is at least some peace in the world.
AAAAA Forum Fanatic Topics: 156 Posts: 1,991	09/04/06 - 10:07 AM             #6 study_ing wrote: Prolonged uterine bleeding suggests the epithelial lining of the cavity has become denuded over time. In this setting, a progestin is unlikely to control bleeding. Estrogen alone will induce return to normal endometrial growth rapidly. Hemorrhagic uterine bleeding requires high-dose estrogen therapy. If bleeding is not controlled within 12-24 hours, a D&C is indicated. High dose estrogen therapy is used for medical use and if the bleding does not stop, hysterectomy may require. D & C is useless in massive bleeding, it just get things worse ! ___________________ seeking study partner in USMLE, Canadian MCC OSCE examination
study_ing Forum Fanatic Topics: 180 Posts: 2,511	09/04/06 - 10:30 AM             #7 hmm im really sorry for posting inaccurate info ..actually i copy pasted it of somewhere and ive forgotten the source. what aaaa is saying seems more sensible...will get back if i remember. ___________________ If you yourself are at peace, then there is at least some peace in the world.

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