Cedrick
Forum Fanatic
Topics: 322
Posts: 2,042
|
that is a very good subject I will search
|
| Cedrick
Forum Fanatic
Topics: 322
Posts: 2,042
|
SSSugar !
my book just fell into 20 pieces
|
| star1
Forum Guru
Topics: 93
Posts: 827
|
First tell me which enzyme is important in salvage pathway?
answer is HGPRT
what reaction is involved in this enzyme?
there are two reaction that involve HGPRT
substrate--------------------------------> Product
Hypoxanthine----------------------------> Inosine
PRPP -------------------------------------cGMP
when these reaction are not proceeded forward, the substrate accumulate
HGPRT is missing in a syndrome very famous what is its name??
|
| Cedrick
Forum Fanatic
Topics: 322
Posts: 2,042
|
Thanks Star
Now I have to glue my book or get a new one !
|
| drpkaur
Forum Guru
Topics: 196
Posts: 810
|
oh thanx star1 for your input.well now i have understood the concept that HGPRT ezyme requires PRPP as source of ribose -5 -phosphate ,and the reactions involved in salvage pathway are-----hypoxanthine_______________IMP
and guanine ______________________________GMP....
in LESCH-NYHAN syndrome HGPRT is missing therefore can't use PRPP leading to high levels of PRPP and no IMP n GMP formed leading to their decrease ....am i right guys...
|
| star1
Forum Guru
Topics: 93
Posts: 827
|
Yes U got it
GL
|
| study_ing
Forum Fanatic
Topics: 180
Posts: 2,509
|
may i stress..this syndrome with the characteristic 'self mutilation' in the clinical vignette is pretty HY..me and loads of my friends got qs to identify it or the related enzyme deficieny in our exams
___________________
If you yourself are at peace, then there is at least some peace in the world.
|
|
| |
| | | | | | | |
Similar forum topics