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Author26 Posts
  #21

GDS2008 wrote:
bleeding, osteoporosis, elevated transaminase, hypokalemia (decreases aldosterone production). However, non is common except bleeding

Kool!!!!!!!!

Heparin does reduce Aldosterone secretion --------------> Hyperkalemia

Agreed It is not very common but can occur with chronic use.

Next Question

A patient with DVT (also has H/O recurrent thrombosis),you put him on Heparin ,inspite of increasing Heparin to heavy doses aPTT still in normal limit.What is wrong with Patient???


  #22

hey Sea_gull. Seems like U have really mastered heaprin pharmacology -- thanks for sharing it with us. To be frank, I have no idea what this patient might have. However, I will make a wise guess, based on how heparin normally works. I would think that the patient lacks Anti-Thrombin III (i.e. anti-thrombin III deficiency).

Also, it was supposed to be hyperkalemia in the last post (not hypokalemia)

  #23

GDS2008 wrote:
hey Sea_gull. Seems like U have really mastered heaprin pharmacology -- thanks for sharing it with us. To be frank, I have no idea what this patient might have. However, I will make a wise guess, based on how heparin normally works. I would think that the patient lacks Anti-Thrombin III (i.e. anti-thrombin III deficiency).

Also, it was supposed to be hyperkalemia in the last post (not hypokalemia)

Excellent Well guessed :

Excellent

It is Anti-Thrombin III deficiency in which Heparin becomes absolutely ineffective.

GL


  #24

Sweet! exam coming up in 4 days and this sounds like a confidence booster--thanks!

  #25

Vow guys excelllent work here...just adding a little detail ( and the only one i know smiling face)

HIT 1occurs within the first 2 days of heparin therapy

possiby due to the direct effect of heparin on plt activation

HIT--4-10 days later

autommune phenomenon as described b4


___________________
If you yourself are at peace, then there is at least some peace in the world.

  #26

Everyone i know who has taken step2 has had a q on this subject. So I applaud you`re enthusiasm and knowledge. Wish u all the best.









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