Sea_gull
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Venodilation ---------> decrease in preload ---------> decrease in work load by myocardium -----------------> decrease in O2 consumption
GL
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| som
Forum Guru
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so it is not the arterial dilation that helps to relieve the pain of angina?
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| Sea_gull
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Major MOA of nitrate to releive anginal pain is "Venodilation".These are also
coronary vasodilator but it also does not help much.These are arterial vasodilators also but in comparatively higher doses.Arterial vasodilation is sometimes harmful because it may lead to Hypotension with reflex tachycardia and aggravation of angina instead of relief.
GL
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| som
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thanx
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| sheeezooo
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sea_gull ..u explain nicely i like it..
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| Sea_gull
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Thanks a lot for encouragement.
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