sridevibandaru24
Forum Guru
Topics: 33
Posts: 434
|
A 2 yr old boy has a unlilateral cleft lip and palate. he has no other
malformations and is otherwise healthy. he has no family hx of birth
defects. His parents are not related. Which of the following genetic
mechanisms is most likely to have caused these congenital abnormalities?
a. autosomal dominant inheritance
b. autosome recessive inheritance
c. chromosomal aneuploidy
d. chromosomal deletion
e. mitochonddrial DNA mutation
f. multifactorial inheritance
g. x linked recessive inheritance
|
| docarchana
Forum Guru
Topics: 70
Posts: 515
|
F
|
| smal
Forum Guru
Topics: 140
Posts: 727
|
i'll go for D.
just coz nothing else seems appropiate to me.
cleft lip and palate is in the baby itself so no mode of inheritance,in my opinion but is an independent event.
all opinions welcomed,thanks
___________________
remedy for weakness is not brooding over it ,but thinking of strength.
|
| muzammil
Forum Guru
Topics: 16
Posts: 664
|
f
|
| sridevibandaru24
Forum Guru
Topics: 33
Posts: 434
|
yup its multifactorial inheritance
|
| smal
Forum Guru
Topics: 140
Posts: 727
|
can u plz explain why its multifactorial sridevibandaru24?
___________________
remedy for weakness is not brooding over it ,but thinking of strength.
|
| blueocean
Forum Senior
Topics: 15
Posts: 195
|
http://www.uic.edu/classes/bms/bms655/lesson11.ht...
|
| rubina
Forum Newbie
Topics: 1
Posts: 21
|
multifactorial
|
| klimt
Forum Guru
Topics: 27
Posts: 605
|
multifactorial
this q is a nbme f1 q, should have been marked so
___________________
Traveler, there are no roads. Roads are made by walking.
|
| mediocre
Forum Elite
Topics: 37
Posts: 229
|
thanx 4 the link bluocean.....this is a gist(drops) from the same
In summary, the hallmarks for multifactorial inheritance are:
Most affected children have normal parents. This is true of diseases and quantitative traits. Most geniuses come from normal parents, most mentally challenged come from normal parents.
Recurrence risk increases with the number of affected children in a family.
Recurrence risk increases with severity of the defect. A more severely affected parent is more likely to produce an affected child.
Consanguinity slightly increases the risk for an affected child.
Risk of affected relatives falls off very quickly with the degree of relationship. Contrast this with autosomal dominant inheritance with invomplete penetrance, where the recurrence risk falls off proportionately with the degree of relationship.
If the two sexes have a different probability of being affected, the least likely sex, if affected, is the most likely sex to produce an affected offspring.
___________________
"Do not worry if you have built your castles in the air. They are where they should be. Now put the foundations under them." - Henry David Thoreau
|
| ManuNastai
|
F
|
| mousa
Forum Senior
Topics: 3
Posts: 64
|
f
|
|
| |
| | | | | | | | | | | | |
