tolito
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how does it occur??? ( in COPD pts)
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| tolito
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is it related to acidosis that usually occurs while sleeping ???
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| som
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wht is MOA?
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| tolito
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sorry, Mechanism of action.
i should have labelled it mechanism of production and not action.
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| GDS2008
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When one sleeps, the brain activity goes down (a normal response) and respiratory centers become less responsive to PaCO2. As a result, relative hypoventilation occurs whihc is responsible for nocturnal desaturation. This goes completely unnoticed in normal individuals. However, in patients with COPD and other chronic respiratory/CVS disease it may be significant. Moreover, the manifestations seen in PNH and gout are partly due to this phenomenon as well....
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| tolito
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thanks. i look at the phenomenon more from the view of the Hb saturation curve with a right shift as O2 is being dumped as a result of the acidosis??
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| GDS2008
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Tolito -- U R absolutely right and that would explain the reason for desaturation better. I guess my explnation fits well with acidosis and urs do a better job in explaining the reason for desaturation (needless to say that respiratory acidosis and desaturation are two completely different things). Thanks for sharing the info
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