thalidomide

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thalidomide

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drpkaur
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08/25/06 - 09:58 AM

Three small placebo-controlled studies suggest that thalidomide can help people with AIDS and tuberculosis gain weight, without adding to immune suppression. What is the possoble action of thalidomide?

a. it inhibits TNF alpha

b. it is an apetite stimulant

c. it decreases nausea and vomiting

d. it increases the absorption of food from the gut

e. it increases fatty acid formation

suv
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08/25/06 - 10:35 AM

thalidomide inhibits TNF alfa

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fox
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08/25/06 - 04:08 PM

yup tnf alpha

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khorshid
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08/26/06 - 07:58 AM

drpkaur
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08/28/06 - 11:14 AM

correct A is the answer,..

aisha2
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09/07/06 - 06:41 PM

plz explain this answer , how can this help gain wt

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aisha2
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09/08/06 - 07:06 AM

here is what i found , the exact mech of thalidomide is not yet known but the inhibition of TNF-alfa is a part of the puzzle, it was initially introduced as an anti emitic during pregnancy , in 1950s, but then with the emergence of teratogenicity ( amelia or phocomelia ) it was taken of the market.

these days it is been used in pts with AIDS. TB and cancer (chemotherapy) to gain wt , probably as an immunomodulator and in leprosy & multiple myeloma , it is been studied for its use in ALS.

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Leopard
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09/08/06 - 08:54 AM

aisha2 wrote:
here is what i found , the exact mech of thalidomide is not yet known but the inhibition of TNF-alfa is a part of the puzzle, it was initially introduced as an anti emitic during pregnancy , in 1950s, but then with the emergence of teratogenicity ( amelia or phocomelia ) it was taken of the market.

these days it is been used in pts with AIDS. TB and cancer (chemotherapy) to gain wt , probably as an immunomodulator and in leprosy & multiple myeloma , it is been studied for its use in ALS.

Actually it is supposed that weight loss in Cancer patients and persons with chronic inflammatory process is due to TNF - alpha.This weight loss is called Cachexia and TNF-alpha is called Cachectin.So antagonizing its action ,will inhibit weight loss.

Best of luck

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drpkaur
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09/08/06 - 09:41 AM

http://www.atdn.org/simple/thalid.html

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