drpkaur
Forum Guru
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The answer is d.
Carbamoyl phosphate (CAP) synthase I is found in mitochondrial matrix and is the first step in urea synthesis, condensing CO2 and NH4+. Hyperammonemia occurs when CAP is deficient.
CAP synthase II forms CAP as the first step in pyrimidine synthesis. Its complete deficiency would probably be a lethal mutation. When its activity is decreased, purine catabolism to uric acid is decreased, decreasing the possibility of hyperuricemia.
In contrast, gout, Lesch-Nyhan syndrome, high xanthine oxidase activity, and von Gierke’s disease [glycogen storage disease type Ia ] all lead to increased urate production and excretion.
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