mahendra
Forum Guru
Topics: 173
Posts: 419
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An 80-year-old woman dies after a long history of progressive memory loss,
apraxia, and recurrent episodes of confusion. In the last months of life she
was bedridden and unable to recognize familiar faces and objects. The
pathologist identifies numerous flame-shaped intracytoplasmic inclusions
in neurons of the neocortex and hippocampus. These consist of paired
helical filaments (PHFs) on electron microscopy. Which of the following
biochemical changes most likely accounts for the development of PHFs in
this condition?
A. Abnormal degradation of amyloid precursor protein (APP)
B. Abnormal phosphorylation of tau
C. Accumulation of advanced glycosylation end (AGE) products
D. Increased expression of APP
E. Precipitation of insoluble a-tubulin
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| meg
Forum Guru
Topics: 62
Posts: 806
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I think it is Alzheimers and the flame shaped filamed NFT are hyperphosphorylated tau proteins
In Alzhemer there are 2 main pathological findings
1) Neurofibrrillary tangles - formed by the hyperphosphorylated tau protein. Tau normally binds and stabilises microtubules which are needed to transport substances from cell body to axon etc. In hyperphosphorylated form, tau is unable to bind microtubules.
2)Senile plaque formed by amyloid (chormosome 21, APP) and synnuclein
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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answer :A
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