Musuq
Forum Guru
Topics: 103
Posts: 425
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1. The following agent inhibits the activity of the enzyme aldehyde dehydrogenase:
A. pyrazole
B. SKF-525-A
C. glutathione
D. disulfiram
E. diethylaminoethyldiphenylpropylacetate
2. Which of the following has the greatest affinity for myocardial tissue?
A. digoxin
B. sodium iodide
C. quinacrine
D. methacholine
3. Which of the following would be least lipid-soluble? A. barbital
B. phenobarbital
C. methylphenobarbital
D. thiopental
4. The form of a drug which is most readily absorbed across biological membranes:
A. ionized
B. protein bound
C. unionized
D. glucuronidated
E. quaternary
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| docarchana
Forum Guru
Topics: 70
Posts: 515
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1 d
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| drpkaur
Forum Guru
Topics: 196
Posts: 810
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1.D-DISULFIRAM
2?
3.B??
4.D(UNIONIZED).
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| giovanni83
Forum Senior
Topics: 24
Posts: 125
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3-->it's MPbarbital, because it has got also the metil gruop, that make more difficult membrane passage...
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| drpkaur
Forum Guru
Topics: 196
Posts: 810
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3.barbital?
Explanation:
Barbital lacks the bulky lipid-like side groups that most other barbiturates have. It has a partition coefficient of ~1 (equally soluble in water vs. lipid). As a consequence it is also poorly absorbed (e.g. 12%).
Phenobarbital and methylphenobarbital are more lipid soluble than barbital because of their side groups.
Thiobarbituates are barbiturates where an oxygen atom is replaced by a sulfur atom. This increases their lipid solubility.
Thiopental is highly lipid soluble with a partition coefficient of ~580
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| giovanni83
Forum Senior
Topics: 24
Posts: 125
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yes you are right...
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| AngelT
Forum Senior
Topics: 32
Posts: 110
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1-D
4-C
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