Musuq
Forum Guru
Topics: 103
Posts: 425
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1) A competitive antagonist:
A. shifts the dose-response curve down and to the right
B. acts at an allosteric site on the receptor
C. shifts the dose-response curve to the left and up
D. acts at the same site as the agonist
E. shifts the dose-response curve only at low concentrations of the compound
2) An antagonist is a type of drug that:
A. has maximal efficacy
B. has affinity for a receptor but little efficacy
C. binds to a receptor and activates it
D. has efficacy but low affinity
E. decreases the concentration of an agonist required to produce an effect
3) Drug affinity for a receptor is most closely associated with a drugs:
A. potency
B. efficacy
C. selectivity
D. toxicity
E. safety
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| drpkaur
Forum Guru
Topics: 195
Posts: 808
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1.D, 2.B
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| drpkaur
Forum Guru
Topics: 195
Posts: 808
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3..C??
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| khorshid
Forum Guru
Topics: 32
Posts: 591
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1.D 2.B 3.C
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| giovanni83
Forum Senior
Topics: 24
Posts: 125
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why 2.b??in my opinion 2-->C Remeber that antagonist sometimes has a receptor on the cell, and thay can activate it. They can activate a receptor, for examples kinases, that low affinity of agonist on others receptors (see Lippincott pharmacology, where it says about adrenaline - B blockers interactions...)
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| drpkaur
Forum Guru
Topics: 195
Posts: 808
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REGARDING Q-2-----Correct answer: B. has affinity for a receptor but little efficacy
Explanation:
A. is wrong because antagonists have little or no efficacy.
B. is correct. Antagonist bind to receptors but do not activate them.
C. is Incorrect because antagonists do not activate receptors.
D. is wrong because antagonists have low efficacy.
E. is wrong. This type of action would be considered a "synergistic" effect with the agonist.
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| giovanni83
Forum Senior
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Posts: 125
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yes you are right....
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| divamil
Forum Newbie
Topics: 0
Posts: 3
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I think 3 is not C, but A - potency. Can someone check on this?
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| AngelT
Forum Senior
Topics: 30
Posts: 100
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I think is A also
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| sridevibandaru24
Forum Guru
Topics: 33
Posts: 434
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1.D
2.B
3.A
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