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Kaplan Qbank USMLE



Author7 Posts
  #1

Which of the following condition may cause hypokalemia with hypertension.
1-21 hydroxlyase deficiency
2-bartter syndrome
3-pheochromocytoma
4-11 beta hydroxlyase deficiency
5-gitelman syndrome

  #2

A?

Tempting to chose Bartter or Gitelman, as they're both associated with hyper-reninism. BUT they both also have characteristically NORMAL BP!

So my guess is A, causing increased ACTH (due to lack of (-) feedback), leading to increased 11-OH-cortisol which has mineralocorticoid activity. Just my guess...?


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First Aid is my Bible...

  #3

4-11 beta hydroxlyase deficiency


  #4

Yes that's right. The concept was there, the correct enzyme wasn't!

It's 11-OH deficiency. Thanks for the correction.


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First Aid is my Bible...

  #5

yeah 4 is the correct answer.in 21 hydroxylase deficiency,patient is hypotensive....good job...
there are more conditions which causes hypertension with hypkalemia.list them...





  #6

sorry for misspelling -hypokalemia..

  #7

well basically anything that inreases Renin/Aldosterone!

-conn's

-B1-agonists

-Renal a. stenosis

...so on...


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First Aid is my Bible...







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