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Author8 Posts
  #1

1. Which of the following types of pulmonary dysfunction may follow heroin overdose?
(A) pulmonary fibrosis
(B) pulmonary edema
(C) bronchospasm
(D) pulmonary hypertension
(E) pneumonitis with eosinophilia


  #2

tricky one:
Opioids do cause brochospasm (release Hist.) but also in overdose state (esp. IV form) due to allergy, Frothy Pulm. edema can also occur !!




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  #3

wats the ans kaurji

  #4

docarchana why don't u try for the posted ques..you keep on asking the answers..i don't mean to hurt you but encourage you to participate in posted ques on forum...

  #5

kaurji, sorry if i offended u.

i dont even know how to approach the ques. so i will be asking for the answer (explanation) from senior members like u. bcos i found that u wont be giving the answers even after many weeks of posting the ques and it wont be helpful for other members in this forum.
so it will be nice if u give the correct ans 3 to 4 days after posting the ques.

sorry for giving a short mail.
goodluck in future.

  #6

pulmonary edema

  #7

yeah it's pulmonary edema.

  #8

I have to agree with drpkaur...if you read other people's explanations, or simply look up the answer by yourself, or google it, you will retain a LOT MORE that way (not to mention covering a lot more bases) then simply being told the answer.

In google, if you just type in "Heroin overdose pulmonary" the first link gives you the answer. So docarchana try to find the answer by yourself. You will benefit a lot more that way than by having drpkaur just tell us the answer.

Something of interest though as to WHY we have pulm edema (if anyone's interested):

The pathophysiology of Pulmonary Edema related to heroin overdose has never been adequately explained. Hemodynamic evaluation of a total of 11 patients with heroin-related Pulmonary Edema demonstrated normal or increased cardiac output, normal pulmonary capillary pressure, and only moderately elevated pulmonary artery pressure. Pulmonary fluid analysis of patients with this syndrome confirmed a much higher protein concentration, as compared to edema fluid from patients with congestive heart failure, consistent with the hypothesis that leaky pulmonary capillaries and not pump failure are the likely cause of heroin-related Pulmonary Edema.

Interesting! Further:

Histamine has been implicated as a possible mediator of Pulmonary Edema related to heroin overdose. Human lungs are rich in histamine, and opiates have been shown to cause its systemic and local release. Histamine has been shown to increase pulmonary lymph flow and capillary permeability. One study of patients with fatal heroin overdoses demonstrated a modest correlation with elevated tryptase levels (a postmortem histamine surrogate), as compared to control subjects......................

http://findarticles.com/p/articles/mi_m0984/is_5_120/ai_80677301/pg_1


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