drpkaur
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A 45-year-old male with alcoholic cirrhosis is seen in the ED because of a laceration of the scalp. Of the following local anesthetics, which would potentially be toxic?
A. Lidocaine
B. Benzocaine
C. Procaine
D. Tetracaine
explain plz
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| khorshid
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A.lidocaine, I think its related to its metabolism(decreases) and bioavailability(increases) in cirrhosis.
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| misgana
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A b/c lidocain is metabolized in liver but the others in tissue esterases
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| Dragonfly
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Amides : Lidocain, Bupivacain, Ropivacain (all have 2x"i"s in their names)
are metabolized in the liver
Esters: cocain, tetracain, etc. are metabolized by tissue esterases.
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| drpkaur
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correct lidocaine is the answer..thanx dragonfly for ur explanation.
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| MRMAVERICK
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YA-LIDOCAINE IS METABOLIZEA IN LIVER-REST ARE ESTERS METABOLIZED BY TISSUE AND PLASMA ESTERASES
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| MRMAVERICK
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AND LIDOCAINE BEING AMIDE IS METABOLIZES BY AMIDASES IN LIVER ONLY 
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245/264/CS pass All on first attempt/2006 Grad/1 month Observership/1 US LOR/Need VISA
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