study_ing
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a 25 yr old lady has difficuly getting pregnant. she mentions her husband has UC. what do u htink of?
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| icemaiden
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PSC and liver failure?
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| study_ing
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nope...good thinking but guess again...
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| tolito
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autoimmune ab"s to sperm?????
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| som
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hmm..interesting to note that drugs used for UC...sulfasalzine, prednisone are associated with male infertility
note this frm http://www.ivf.com/shaban.html which says:
Sometimes glucocorticoid excess (prednisone usage) is exogenous in the therapy of ulcerative colitis, asthma, or rheumatoid arthritis. The result is decreased spermatogenesis. The elevated plasma cortisone levels depress LH secretion and can cause secondary testicular dysfunction. Correction of the glucocorticoid excess results in improvement in spermatogenesis
also it is sulfasalzine (not ASA)that is associated with reversible male infertility in pts being treated with it for UC. alternative is mesalazine or ASA...not able to post tht link here.
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| study_ing
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brillaint som! hit it right on the mark 
i just had sulfasalazine in mind to be honest ..
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| cbenitesch
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I think infertility is due to UC, but papers say is not very common for males. They have a slightly low rate for infertility during active disease.
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| cbenitesch
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If you think on sulfasalazine... it can cause oligospermia with doses over 8g/day, so.. a patient can tolerate only 4g/day. Maybe prednisone can induce this kind of infertility
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| study_ing
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well i mentioned this point keeping in mind what kaplan had mentioned.
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| robin082006
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