drpkaur
Forum Guru
Topics: 196
Posts: 810
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A 54 yr olde female has reporting to your office with complain of incresing voiding, dry mouth and profuse sweating at night. her blood glucose level is 248 mg/dl. the patient present with the following lipid profile too..
HDL...27 MG/DL
LDL...185 MG/DL
TG...495 MG/DL
what theurapetic agent would give an increase in HDL and decreases in TG?
1..glyburide
2..repaglinide
3...pioglitazone
4...acarbose
5..insulin
6...metformin
7...niacin
8..gemfibrogil
9..lovastatin
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| mitty
Forum Guru
Topics: 52
Posts: 376
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7
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| khorshid
Forum Guru
Topics: 32
Posts: 591
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8 gemfibrozil(decreases TG, increases HDL a bit and also potentiates hypoglycemics, so good in this pt)
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| docarchana
Forum Guru
Topics: 70
Posts: 515
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both gemfibrozil & niacin cause increase in HDL & decrease in TG. wats the ans kaurji.
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| Nan
Forum Senior
Topics: 12
Posts: 159
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One of the side effects of Niacin is hyperglycemia. It isn't the drug choice for a patient with DM. 8 Gemfibrozil
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| docarchana
Forum Guru
Topics: 70
Posts: 515
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thanku Nan.
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| drpkaur
Forum Guru
Topics: 196
Posts: 810
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symptoms suggestive of diabetes mellitus........and there is lipid profile is also abnormal....so we have to manage both......
answer is pioglitazone......
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| docsrinu
Forum Elite
Topics: 26
Posts: 213
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drpkaur, whats the moa of pioglitazone. i checked in kaplan but the drug is not mentioned.
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| MRMAVERICK
Forum Guru
Topics: 46
Posts: 931
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pioglitazone belongs to thiazolidenediones-mechanism of action of these drugs is that it stimulates PPAR-gamma receptors-the nuclear receptor regulates transcription of genes encoding proteins involved in CHO and fat metabolism
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| docsrinu
Forum Elite
Topics: 26
Posts: 213
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thanku maverick.
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