amitdoc2b
Forum Senior
Topics: 42
Posts: 97
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A clone of cancer cells is resistant to vincristine, doxorubicin, and dactinomycin but not to methotrexate and various alkylating agents. The mechanism of resistance is most likely to involve:
a) absence of superoxide dismutase
b) altered DNA polymerase
c) enhanced drug transport out of cell
d) inability to form polyglutamate
e) increased DNase
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| drpkaur
Forum Guru
Topics: 196
Posts: 810
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C-resistant cells have been shown to have an enhanced efflux of vincristine,dactinomycin via P-glycoprotein in the cell membrane.
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| twesting2173
Forum Senior
Topics: 7
Posts: 65
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dont want to be annoying with the q, but how do people know this? was this just memorized or did you rationalize this out somehow? i get the poop scared out of me b/c i have no clue about questions like this. i happened to guess right on this one but it does not happen very often. thanks.
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| fongch
Forum Elite
Topics: 71
Posts: 316
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C will probably result in resistance to methotrexate too, right?
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| Musuq
Forum Guru
Topics: 103
Posts: 425
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what the heck with this qs, oh boy, way to go drpkaur
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| me007
Forum Guru
Topics: 72
Posts: 799
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something here
http://www.ionchannels.org/showabstract.php?pmid=...
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