amitdoc2b
Forum Senior
Topics: 42
Posts: 97
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Hi!!
I wanted to thank everyone who has helped me out with the NBME questions for this topic. But I still have some questions that were are unanswered and my exam is in 2 weeks!  Can you please help me out with them? I wanted to understand also why it is the correct answer and I have been having trouble finding the reasoning behind these particular questions.
I've attached 2 files in this topic, I have to do it in separate replies cuz it only lets me attach one file at a time..
Thanks!!
Attached Files:
immuno_1.JPG (115 KB, 192 downloads)
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| amitdoc2b
Forum Senior
Topics: 42
Posts: 97
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here's the second file..
Attached Files:
immuno_2.JPG (156 KB, 103 downloads)
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| sridevibandaru24
Forum Guru
Topics: 33
Posts: 434
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14. a(bradykinin induces Hyperalgesia)
18. e
25.B
37.A?
15.D'(IL 1 activates T and B cells)
12.D?
24.B(DiGeorge syndrome with thymic aplasia ,hypocalcemia,viral infections due to decreased Tcell count and congenital heart anamolies)
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| amitdoc2b
Forum Senior
Topics: 42
Posts: 97
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thanx sri devi... can anyone please explain #25's answer and help with the ones Sri Devi is not sure about? thanx..
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| Musuq
Forum Guru
Topics: 103
Posts: 425
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Let me help you to visualize the qss
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| Musuq
Forum Guru
Topics: 103
Posts: 425
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25.
B)Immunoglobulin Isotype Switching?
For Opsonization IgG and C3b are needed. So, I would think that the B lymphocyte is not doing the switching from IgM to the rest Igs, in this case to IgG, it could be a CD40L defect 9 or IL4-5 absence. Correct me if I am wrong please,
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| keepgoing
Forum Fanatic
Topics: 92
Posts: 2,146
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hey musuq gr8 work!
well plz correct me i think ans for 14 --->"c5a" as C3a and C5a cause inflammation at the site of infection by activating local blood vessels to induce recruitment of phagocytes of the innate immune response or i misunderstood the question
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| pkb
Forum Newbie
Topics: 3
Posts: 14
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(http://jcp.bmjjournals.com/cgi/content/full/55/4/...
The diagnosis is classically confirmed by the low C`4 concentration in the serum and in most cases by low amounts of C`1 inhibitor protein, as assessed by immunohistochemistry. If C`1 inhibitor values appears normal or raised and C`4 is low, a test of C`1 inhibitor function should be carried out.9,28 All such tests should be carried out on a fresh serum sample—one less than four hours old
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| pkb
Forum Newbie
Topics: 3
Posts: 14
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(http://jcp.bmjjournals.com/cgi/content/full/55/4/...
C'1 esterase inhibitor deficiency
The diagnosis is classically confirmed by the low C`4 concentration in the serum and in most cases by low amounts of C`1 inhibitor protein, as assessed by immunohistochemistry. If C`1 inhibitor values appears normal or raised and C`4 is low, a test of C`1 inhibitor function should be carried out.9,28 All such tests should be carried out on a fresh serum sample—one less than four hours old
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| ManuNastai
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I'd say
15 D
12 B
24 A
14 A
18 E
25 B
37 A
I may bewrong, though
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| me007
Forum Guru
Topics: 72
Posts: 799
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about #24
If it is Di George - normal B, decreased T and thymic hypoplasia - narrowed mediastinal shadow -
should be ans C?
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| ManuNastai
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for a normal antibody response (Ab mediated immunity), you need functional CD4+ T cells
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| me007
Forum Guru
Topics: 72
Posts: 799
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hi, ManuNastai!
Why did you pick B for #12?
i think D - they mention HLA type
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| smal
Forum Guru
Topics: 140
Posts: 727
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B coz MCH II will pick up the Ag ,coded by HLA 2.
dont know if i solved ur query
.........
i couldnt follow #15?i just saw a likn abt studies in old mice saying there is defct in IL2 ,thats the main reason for dec. production of IL1 by macrophages.but is there any way anyone can explain it plz?
thanks
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| NE
Forum Guru
Topics: 53
Posts: 504
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I think 24 is a very picky q because - "evaluation of humoral immunity reveals variable immunoglobulin levels and depends on the extent of T-cell deficiency. As would be expected (ie, because normal B-cell development requires normal T-cell function), the B-cell repertoire is normal in patients whose only measurable T-cell defect is a low number. Patients with partial DiGeorge anomaly generate good antibody response to protein vaccines, but no data are available on polysaccharide vaccines. Increased prevalence of immunoglobulin A deficiency has been observed in 4 of 32 patients with 22q11.2 deletion". So between A and C it is hard to decide...
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| girl^interrupted
Forum Elite
Topics: 68
Posts: 264
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I did get all the questions except q-12..
Plz anybody explain why B?
The non responders cant make antibody ...so the defect can either be:
A or D......
But I guess Im missing out on something.....Why is one HLA type frequecy increased?
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