zhangrong12003
Forum Senior
Topics: 5
Posts: 15
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gout is due to lack of inhibition of PRPP synthatase or PRPP aminotransferase?
is G6pd associated with gout?
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| young_doc
Forum Guru
Topics: 55
Posts: 732
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G6PD is 'kinda' associated with gout. This association is seen only with Von-Gierke's. If G6P can't go to Glucose, it will build up and forced through the G6PDH reaction. As we all know , the end product of this pentose phosphate reaction is Ribose-5-P...or NUCLEIC ACID! And what happen when we build up too much nucleic acid? There's your associated with G6PDH and gout.
As far as i remember, the PRPP enzymes are in pyrimidine synthesis, and i so can't see how they are associated with gout. Or maybe i'm just too tired right now to remember :S
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| zhangrong12003
Forum Senior
Topics: 5
Posts: 15
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i buy ur point as to G6PD.
PRPP aminotransferase is the rate limiting step in purine catabolism. PRPP synthatase leads to PRPP production. i am sure either of them or both will cause gout.
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| tinabg
Forum Newbie
Topics: 2
Posts: 22
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Another reason for gout in Von Gierke's is lactic acidosis. Lactic acid competes with uric acid for excretion, therefore, wherever you have lactic acidosis you are going to have gout. This is also the reason why alcoholics get gout.
Loss of inhibition of either PRPP amidotransferase or synthetase wil cause increased purine synthesis. Hence, catabolism will be increased as well, which leads to gout.
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