study_ing
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there are different pathways involving dopamine in the brain ( i think 4). when the nigrostriatal pathwy is involved, Parkinson's symptoms manifest.
in hyperPRL a different axis is involved...check introductory sections to antiparkinson drugs in katzung or kaplan.
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| study_ing
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unfortunately with drugs, we can not pinpoint the pharmacological agent to its target area:hence the side effects.
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| Dragonfly
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study_ing is right.
let`s not forget that in Parkinson`s, the loss is focal, (only substantia niagra) but hypothalamus is intact.
there are 4 main DAergic pathways in the CNS:
1- Niagrostrial (involved in parkinson)
2- Mesolimbic (Schizophrenia)
3- paraventricular (satiety center)
4- Tuberoinfundibular (PL secretion)
drugs can affect all pathways, hence the side effects. but parkinson only hits the first one.
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