dr_bilalahmad
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32. Latent infection with which of the following viruses is associated with expression of some (but not all) viral genes in B lymphocytes?
A) Epstein-Barr virus
B) Hepatitis B virus
C) Measles virus
D) Simian virus 40
E) Varicella-zoster virus
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| star1
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A
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| dr_bilalahmad
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hey star ....can EBV be latent??
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| Dragonfly
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sure it can!!
haven't you heard about Recurrence of Infectious mono? Brukitt's lymphoma? nasopharyngeal carcinoma?
the whole herpadnevirus family can be Latent. HSV, VZV, CMV, EBV, HHV8
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| Neuroine
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E VZV
During latency, most - if not all - viral DNA is located in the cytoplasm rather than integrated into nuclear DNA
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| aisha2
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ill go with A. EBV
usual site of latancy
HSV-1----------- cranial sensory ganglia
HSV-2----------- lumbar / sacral sensory ganglia
VZV------------- cranial / thoracic sensory ganglia
EBV------------- B lymphocytes
CMV------------- uncertain (may be latent within criculating lymphod cells or epithelial cells)
refer: jawadz table 37-1
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| docarchana
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thanx aisha. very informativ.
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| docsrinu
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HSV-1 latent in trigeminal ganglia.
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| qumsieh
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Out of the choices above only A) EBV has a latent effect in the B -lymph cells. example is Burketts Lymphoma. The next best answer would be VZV but that is latent in nerve dermatomes. In addition, HSV may also be latent in the trigeminal nerve causing a common patholgy called "cold sores" . Hope this helps.
Ross University Graduate
Massachusetts General Hospital
Harvard College
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