drsnm
Forum Junior
Topics: 12
Posts: 28
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where is effect of nitric oxide on cross section of blood vessel?
it's in endothelium or muscular ?
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| drpkaur
Forum Guru
Topics: 196
Posts: 810
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Endothelium-derived relaxing factor (EDRF) was the tentative name of what was later discovered to be nitric oxide (NO). It is released by the vascular endothelium in response to a variety of chemical and physical stimuli. It causes the smooth muscle in the vessel wall to relax by activating the soluble guanylate cylclases (sGC), increasing the cyclic guanosin monophosphate (cGMP)concentration and activating the cGMP-dependend Proteinkinase I (cGKI), resulting in vasodilation. It is also the active substance absorbed into the blood stream by people using nitroglycerin tablets or spray under their tongue, by patch, pill or intravenous infusion of nitroglycerin.
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| docswapna
Forum Senior
Topics: 61
Posts: 229
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produced in endothelium.
action on smooth muscle.
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