asmi
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What is triple screen (for diagnosis of down's syndrome) ?
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| Idiopathic
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Triple screen tests for: beta HCG, placental estrogen, and alphat-fetoprotein. It will be positive in cases of neural tube defects (anencephaly, spina bifida) or in some chromosome abnormalities (Down's)
High AFP correlates with a neural tube defect
High estrogen and beta HCG but low AFP indicate possible chromosome abnoramlity.
The test is about 50% specific, and an amniocentesis is the test of choice for the confirmatory chromosome test, while I believe ultrasound tests for the neural tube defects.
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| asmi
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yes right.
Thanks idopathic 
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