yet another NBME 2...!

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yet another NBME 2...!

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4 Posts

young_doc
Forum Guru
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Topics: 55
Posts: 732

08/11/06 - 07:41 PM

How do we elongate the t1/2 of a peptide...?

-ensuring it has a free N-terminal

-ensuring it has a free C-terminal

-substituting D-a.a. for L-a.a.

-decreasing the number of a.a. in the peptide chain

someone please explain!!!! =)

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study_ing
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Topics: 180
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08/11/06 - 10:59 PM

i think the ans shud be d. the enzyme specificity for d vs the l-aa is different. hence the half- life is likey to be different if the metabolic ez cant work the same way.

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study_ing
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08/11/06 - 11:00 PM

i dont think the n or c terminal matter coz endopeptidases exist...decreasing aa wud not decrease t half

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docswapna
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Topics: 61
Posts: 229

09/23/06 - 05:06 PM

substitutin D for L

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