drpkaur
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A 57-year-old woman with paroxysmal supraventricular tachycardia (PSVT) takes an antiarrhythmic drug for maintenance therapy. When she begins treatment with omeprazole for a concomitant medical disorder, she experiences signs of drug toxicity. Serum samples indicate toxic levels of the antiarrhythmic drug. The best explanation regarding this drug’s toxicity is that it is
Answer Choices Correct answer Your answer
A. unstable at higher pH levels
B. a weak acid with decreased renal clearance
C. a weak acid with increased absorption
D. a weak base with decreased renal clearance
E. a weak base with increased absorption
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| vallia
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Not sure but E?
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| Ivil
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It is E. Omeprazole increase pH in stomach. It has nothing todo with renal clearance.. so B and D are ruled out. If pH is increased, there will be less absorption of weak acid. C is ruled out. if the drug is unstable , it would disintegrate. it cant be a reason for increased toxic levels.
and increased ph will increase the absorption of a weak base drug. so the ans is E.
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| drpkaur
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correct answer is E..well explained Ivil.
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