drpkaur
Forum Guru
Topics: 195
Posts: 808
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PACLITAXEL:MOA-
Paclitaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, paclitaxel arrests their function by having the opposite effect; it hyper-stabilizes their structure. This destroys the cell's ability to use its cytoskeleton in a flexible manner. Specifically, paclitaxel binds to the β subunit of tubulin. Tubulin is the "building block" of microtubules, and the binding of paclitaxel locks these building blocks in place. The resulting microtubule/paclitaxel complex does not have the ability to disassemble. This adversely affects cell function because the shortening and lengthening of microtubules (termed dynamic instability) is necessary for their function as a mechanism to transport other cellular components. For example, during mitosis, microtubules position the chromosomes during their replication and subsequent separation into the two daughter-cell nuclei.
sIDE EFFECTS:
NEUTROPENIA,HYPERSENSITIVITY RX'S,HYPOTENSION,TRANSIENT BRADYCARDIA,PERIPHERAL NEUROPATHY,GI DISTURBANCES,ALOPECIA,ARTHRALGIA,MYALGIA..
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| study_ing
Forum Fanatic
Topics: 180
Posts: 2,511
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menmonic PACKletaxel likes to keep the spindle PACKED.
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| docarchana
Forum Guru
Topics: 70
Posts: 515
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excellent explanation kaur ji..
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