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Kaplan Qbank USMLE



Author14 Posts
  #1

Item 2 and 3:
A. ATGCAA-ATGTAA
B. ATGAAA- GTGAAA
C.TATAAG- TCTAAG
D.CTTAAG- GTTAAG
E. ATGAAT- ATGCAT
The options above represent mutations in the DNA with base changes indicated in boldface type. For each mutation described in the question below, choose the most closely related sequence change in the options above.
3. Mutation decreasing the initiation of transcription

I didnt understand this question..please anybody could help me?
; )





  #2

ok lets do it with a series of qs..

1.what is the initiation codon angel


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  #3

2. whats the difference btw RNA and DNA as far as bases are concerned?

t instead of a U

hence u look for the option where ATG is changed...






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If you yourself are at peace, then there is at least some peace in the world.

  #4

im sorry im done with step 1 so dunno where i ve dumped my books...if u cud expand on the qs id explain them..if ur worried abt copy right, send a PM..or post them then delete em

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If you yourself are at peace, then there is at least some peace in the world.

  #5

Your first question:
Boldface type after arrow (-)
A. Second T
B. First G
C. C
D. First G
E. C


  #6

Whats your e-mail?



  #7

so i guess we see that b is the option where ATG is converted to GTG hence it wud be the answer

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  #8

God what is this...and is it possible to pass step1 without knowing it.......?

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  #9

Thats the problem..the answer is not B...the right answer is C!!! The question is not about translation! But anyway, I still didnt undertand the answer.

  #10

OH mY god ..im so sorry they r talking about transcription NOT translation...hence u look for a change in the TAT sequence

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If you yourself are at peace, then there is at least some peace in the world.

  #11

TATA sequence

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  #12

so its c

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If you yourself are at peace, then there is at least some peace in the world.

  #13

ok, I got it , the sequences that initiate transcription in eukaryotes are TATA box and CAAT box. So mutation in TATA will decrease transcription.

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  #14

about the other question it is a splice mutation because of deleting an entire exon and consequently the 41 AA. It can't be a silent mutation , in which we have a altered codon which also codes for the original AA and nothin is lost.

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