drugs causing autoimm hemolytic anaemia

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drugs causing autoimm hemolytic anaemia

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leftfoot
Forum Elite

Topics: 29
Posts: 216

01/24/04 - 09:52 AM

drrugs causing autoimmune hemilytic anaemia...

cold autoimmune hemolytic anaemia....
1. penicillin
2. methyl dopa

warm autoimmune hemolytic anaemia
1.quinidine
2.isoniazid

can anyone give more examples and add to this list?

Idiopathic
Forum Guru

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Posts: 641

01/24/04 - 10:27 AM

Warm:
type II rx from anti-penicillin IgG located on RBC's.
type II rx from anti-Rh IgG against Rh antigens altered by methyldopa
SLE (MCC) - spherocytosis, Hgb<5.

Cold:
type III immune complex (IgM) from quinidine and idoniazid
infections with Mycoplasma, mono, CLL

For a pnemonic, I remember "It's cold in michigan" (cold anemia, IgM, cll, infectious mono, mycoplasma)

remember cold anemias cause intravascular hemolysis (IgM settling on basememnt membrane causes complement mediated lysis) and warm anemias cause extravascular hemolysis (IgG opsonization and splenic distruction).

meg
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Posts: 806

01/24/04 - 12:49 PM

"Idiopathic" wrote:
Warm:
SLE (MCC) - spherocytosis, Hgb<5.

Hi idiopathic,
thanks smiling face

but please could you elaborate on the SLE aspect you have mentioned... is there an association with SLE and spherocytosis with Hb<5 ?

Idiopathic
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01/24/04 - 04:59 PM

Yes. In autoimmune hemolytic anemia associated with SLE, you will of course have a positive direct Coombs but also you should notice spherocytes in the PB smear and the Hgb will be very low. If I am not mistaken this is a very common cause of death for SLE Px, but I am not 100% sure.

asmi
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Topics: 1043
Posts: 4,609

01/24/04 - 05:21 PM

autoimmune hemolytic anemia is a potential complication in SLE but the commonest cause of death is due to renal disease( diffuse proliferative GN) and infections.

leftfoot
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Topics: 29
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01/24/04 - 09:33 PM

thanks idiopathic and asmi....
...direct coombs is positive is all autoimmune anaemias....cold and warm.

bluestar
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05/30/04 - 07:40 PM

then does quinidine and idoniazid ilicit cold or warm autoimmune hemolytic anemia? posts here seem to contradict each other?

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Idiopathic
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05/30/04 - 09:17 PM

Im sorry, my old post was wrong...quinidine, INH and penicillin all cause warm autoimmune hemolytic anemia...just remember the main cause of cold: lymphoma, mono, mycoplasma, and the rest are warm.

bluestar
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05/30/04 - 10:31 PM

thanks. and the reason why these are warm and those are cold? idiopathic. :P

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Idiopathic
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05/31/04 - 01:11 AM

#10

Its Warm in Georgia (IgG coats the antigen and is cleared by the spleen - coagulates on a slide at 37C)

Its Cold in Michigan (IgM coats the antigen and settles in the vessels; cleared by complement - coagulates on a chilled slide at 4C)

bluestar
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Topics: 236
Posts: 724

06/02/04 - 11:01 PM

#11

thank you very much!

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