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drpkaur
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08/08/06 - 09:12 PM

A histological section of the left ventricle of a deceased 28-year-old white male shows classic
contraction band necrosis of the myocardium. Biological specimens confirm the presence of cocaine and
metabolites. Activity of which of the following enzymes was most likely increased in the patient's
myocardial cells shortly prior to his death?

A. Phosphoenolpyruvate carboxykinase

B. Phosphofructokinase-1

C. Pyruvate dehydrogenase

D. Succinate dehydrogenase

E. Transketolase

drpkaur
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08/17/06 - 09:21 AM

guys try this ques too with explanation plz.

blueocean
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08/17/06 - 12:41 PM

I think is C- cocaine blocks the reuptake of NE which means more NE for the heart. NE stimulates the heart which means more ATP from TCA.

MRMAVERICK
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08/17/06 - 01:30 PM

classic contraction band necrosis means it was coagulative necrosis-more lactate was presnt which means more glycolysis and pfk is rate liming enzyme of glycolysis so b

MRMAVERICK
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08/17/06 - 01:31 PM

correct me if i m wrong

vanshita
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08/17/06 - 02:17 PM

answer b

anaerobic glycolysis

khorshid
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08/18/06 - 07:57 PM

B more NE available, more ATP needed, heart muscles use more Glycogen---->PFK-1

icemaiden
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08/18/06 - 09:20 PM

Sea_gull
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08/20/06 - 02:07 PM

Surely it is activation of PFK-1.Reason is
Cocain causes very severy coronary spasm ----------> myocardial ischemai --------------> depletion of ATP

So ATP ----------> AMP which is powerful activator of PFK-1

drpkaur
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08/20/06 - 02:11 PM

#10

classic contraction band necrosis means it was coagulative necrosis-more lactate was present which means more anaerobic glycolysis and pfk is rate liming enzyme of glycolysis so b..

correct b...

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