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drpkaur
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08/03/06 - 10:20 AM             #1

Here is the ques:
9 mo old baby is evaluated for hemolytic anemia. The oxygen dissociation curve is shifted to the right. Which enzyme deficiency is most likely related for this Pt's condition?



dr_bilalahmad
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08/05/06 - 03:12 PM             #2

its pyruvate kinase deficiency in glycolysis pathway.it causes increased 2-3 bisphosphoglycerate and shifts oxy-hb curve 2 right.due 2 inadequate ATP in rbcs NA-K ATPase function decreases and rbc swells which leads 2 osmotic fragility.rbc loses its biconcave shape and signaled for destruction.....leadin 2 hemolytic aneamia

muzammil
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08/06/06 - 12:47 PM             #3

pyruvate kinase i agree







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