Lim
Forum Elite
Topics: 62
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A genetically engineered clathrin gene mutant expresses only the carboxy-terminal third of the clathrin heavy chain, which trimerizes and folds to reproduce the central hub of clathrin polymers. The presence of a single copy of this mutant clathrin gene in a cell prevents normal clathrin polymerization. Clathrin polymerizing with the mutant clathrin forms an open lattice rather than the normal closed clathrin polyhedron. Which vesicle-mediated movements would most likely be inhibited in a cell containing this mutation?
A. Delivery of lysosomal enzymes to the lysosomes in epithelial cells.
B. Pinocytosis by fibroblast
C. Retrieval of protein disulfide isomorase(PDI) from the Golgi apparatus back to the endoplasmic reticulum in epithelial cells.
D. Transcytosis via vaveolae in endothilia
E. Transport of glycosylases from the endoplasmic reticulum to the Golgi apparatus in epithelial cells.
answer&expl.
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| dr_bilalahmad
Forum Newbie
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Posts: 18
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i guess B is the answer
mutation in clathrin will produce defect in endocytosis..b seems 2 b better choice...
anybody with another explanation???
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