mitty
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A 19-year-old man with a genital herpes simplex virus (HSV-2) infection is treated with acyclovir but fails to respond to the drug. This therapy is stopped, and foscarnet treatment is begun. Within 1 week, the patient’s condition improves. The most likely explanation for the patient’s failure to respond to acyclovir was that the infecting HSV was a mutant strain that lacked
A. cytosine deaminase. B. DNA polymerase. C. reverse transcriptase. D. thymidine kinase. E. thymidylate synthase.
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| robin082006
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D
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| sigmadx
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ditto
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| sridevibandaru24
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D
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| young_doc
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Acyclovir needs to be Phosphorylated 3 times in order to be activated. The first time it's done by the viral thymidine Kinase. The other 2 times it's done be host kinases.
So mutation in the viral thymidine kinase would prevent Acyclovir from being activated.
D!
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