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8 Posts

mitty
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07/23/06 - 11:55 AM

A 60-year-old man with a history of cirrhosis of the liver owing to alcohol complains of chronic skin lesions. Physical examination shows blisters and pigmented scarring on his arms and other body parts that are exposed to sunlight. The patient’s urine sample has a light red-brown color. Urinalysis most likely would indicate an elevated level of

a delta-aminolevilunic acid

b bilirubin

c porphobilinogen

d urobilinogen

e uroporphryinogen

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plastic_girl
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07/23/06 - 01:25 PM

C

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yasmeen
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07/23/06 - 01:30 PM

C ITS PORPHYRIA

spjokes
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07/23/06 - 01:40 PM

E- uroporphyrinogen
and uroporphyrin

PORPHYRIA CUTANEA TARDA due to alcohol

star1
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07/23/06 - 02:41 PM

in acute intermittent porphyria ..... NO PHOTOTOXICYTY

mitty
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07/23/06 - 03:20 PM

yes it is E

it is porhyria cutanea tarda which is due to deficency of the enzyme uroporphyrinogen decarbpxylase and they will have photosensitivity and elevated uroporphyinogen in urine.

elevated porphobilinogen is found in in acute intermittent porphyria which is due to deficency of uroporphyinogen syntase(porphobilinogen deaminase) and their is no photosensitivity.

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mjl1717
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07/23/06 - 05:09 PM

mitty wrote:
yes it is E

it is porhyria cutanea tarda which is due to deficency of the enzyme uroporphyrinogen decarbpxylase and they will have photosensitivity and elevated uroporphyinogen in urine.

elevated porphobilinogen is found in in acute intermittent porphyria which is due to deficency of uroporphyinogen syntase(porphobilinogen deaminase) and their is no photosensitivity.

Good mitty! In addition Rx may be phlebotomy and a little chloroquine, they get Blisters-{this is for PCT which is the most popular porphyria.. Also just saying the word "porphyria" says NOTHING since this is such a large group to master! {thats about as nebulous as saying he has dis-ease} [As mitty said Photosensitivity is a key word]

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study_ing
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07/24/06 - 05:06 AM

thanx mitty
u always post great questions!!

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