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Kaplan Qbank USMLE



Author13 Posts
  #1

well apart from those in the autonomic system in mnemonics
, i dunno any thing


1.insulin
2. GHRH
3. IGF
4. GH
5. glucagon



1. tyrosine kinase
2. Gs
3.tyrosine kinase
4. forgot
5. cAMP so Gs


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  #2

lucky me found a relevant post
http://www.prep4usmle.com/forum/comments.php?id=3...

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If you yourself are at peace, then there is at least some peace in the world.

  #3

here's a summary of what i learnt
TSH,GHRH, PTH, glucagon use Gs
thyroxine uses thy horm receptor which functions like a steroid .. gene expression
insulin and growth factors use tyr kinase
vasopressin uses gq.


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If you yourself are at peace, then there is at least some peace in the world.

  #4

Vasopressin: V 1 is Gq

V2 is Gs
as I remember EDGF is also related to tyrosine kinase





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If you yourself are at peace, then there is at least some peace in the world.

  #5

Angiotensin 1 rc?
ag II?

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If you yourself are at peace, then there is at least some peace in the world.

  #6

glucagon, adenosine, some 5HT,ADH, TSH utilise CREB

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If you yourself are at peace, then there is at least some peace in the world.

  #7

what is the difference between V1 and V2 receptors??

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  #8

brain vs kidney maybe??

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If you yourself are at peace, then there is at least some peace in the world.

  #9

V2 works in the kidneys (water re-absorb)
V1 works in the vasculature (vasoconstrict...notice how it's Gq, hence increase intracellular Ca...hence vasoconstrict).

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  #10

AngiotensinII acts via Gq coupled proteins-activating phospholipaseC and therefore increasing 2 nd messengers-Ca2+ ,IP3 and DAG...

  #11

Then how does GH ,prolactin works?.which 2nd messengers do they use?

  #12

The prolactin receptor is hard to look ip. It seems to be a member of the cytokine receptor superfamily. Hence, like other members of the family, it has a single TM domain, and no intrinsic signalling activity. (http://www.hprd.org/protein/01457)

The GH receptor is a Tyr kinase receptor..(hence your everday dimerization, autophosphorylation...etc).


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First Aid is my Bible...

  #13

PDGF acts via kinases...

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