tolito
Forum Fanatic
Topics: 119
Posts: 2,174
|
injuries and zones affected?
___________________
It has been a looooong hard journey but I am inches away from my destination...
|
| tolito
Forum Fanatic
Topics: 119
Posts: 2,174
|
ok here goes, i found it.
peri-triad
feso4 poisoning
pre-eclampsia
centrilobular ( zone iii)
generally toxins and ischaemia
alcohol
acetaminophen
ccl4
ischemia
what happens in Zone II???
___________________
It has been a looooong hard journey but I am inches away from my destination...
|
| study_ing
Forum Fanatic
Topics: 180
Posts: 2,511
|
yellow fever
___________________
If you yourself are at peace, then there is at least some peace in the world.
|
| study_ing
Forum Fanatic
Topics: 180
Posts: 2,511
|
heres how i try to figure it out
zone II has one unique one--yellow fever
___________________
If you yourself are at peace, then there is at least some peace in the world.
|
| study_ing
Forum Fanatic
Topics: 180
Posts: 2,511
|
zone III has two features
1) its nearest the vein hence more likely to suffer from ischemia
2) SER richest over here..hence those metabolised by P4450 eg CCL4, alcohol are more likely to affect this zone
toxin concentration wud be highest near the arterial end..hence inflowing ones are more likely to affect this zone..
plz remember this is my personal logic so i cud be wrong...but it helps me in my mcqs
___________________
If you yourself are at peace, then there is at least some peace in the world.
|
| study_ing
Forum Fanatic
Topics: 180
Posts: 2,511
|
those inflowing ones which rnt metabolised by P450 remember
___________________
If you yourself are at peace, then there is at least some peace in the world.
|
| tolito
Forum Fanatic
Topics: 119
Posts: 2,174
|
can you list a few more of those involving zone I?
THANKS
___________________
It has been a looooong hard journey but I am inches away from my destination...
|
| ts97
Forum Senior
Topics: 13
Posts: 128
|
I remember that zone I will be affected by auto-immune processes, but cannot recall any examples.
Zone III - also "nutmeg liver"
|
| robin082006
Forum Hero
Topics: 471
Posts: 5,125
|
According to Kaplan,
zone 1 (periportal sone): Toxic injury
Zone 2 (intermed: ischemiiate): no special for injury
ZOne 3 (pericentral vein zone) ischemia.
___________________
The Key to Succeed is Patience.
|
| ts97
Forum Senior
Topics: 13
Posts: 128
|
For zone I - it's acute hepatitis, Primary biliary Cirrhosis and Primary Sclerosing Cholangitis (because of intrahepatic bile duct obstruction - "inflamation and necrosis of the adjacent periportal hepatic parenchyma" Robins 7th p.622). On secondary biliary cirrosis it said "periportal fibrogenesis".
|
|
| |
| | | | | | | | | | |
