asmi
Forum Hero
Topics: 1043
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Can anybody tell me the mechanism of action of 6-Mercaptopurine.
Its a purine antimetabolite,but can you explain me in detail its MOA(mech. of action)
Thanks in advance <:from_book:>
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| mjl1717
Forum Hero
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The ribose phosphate form can inhibit de novo purine ring syn.,as well as AMP and XMP from inosinic acid
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| asmi
Forum Hero
Topics: 1043
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What about HGPRT ?
Does it inhibit it ?
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| meg
Forum Guru
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HGPRT activates 6MP and the activated form then inhibits purine synthesis
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| asmi
Forum Hero
Topics: 1043
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thanks meg.
now i have clear idea about it.
thus the neoplastic cells show resistance to 6MP by inactivation of gene encoding hypoxanthine phosphoribosyl transferase.
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| meg
Forum Guru
Topics: 62
Posts: 806
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yes, you are right about the resistance to 6MP
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