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Author6 Posts
  #1

A 59-year-old woman with advanced, metastatic lung cancer develops profound fatigue and weakness and alternating diarrhea and constipation. Physical examination demonstrates hyperpigmentation of skin, even in areas protected from the sun. Tumor involvement of which endocrine organ is most strongly suggested by this patient's presentation?

A. Adrenal gland
B. Endocrine pancreas
C. Ovaries
D. Pituitary gland
E. Thyroid gland

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  #2

A--addison's disease due to tumor mets and hence hyperpigmentation

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  #3

nod

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  #4

A

  #5

Addison's disease may present with a wide range of symptoms and signs, including weakness, malaise, anorexia, hyperpigmentation (especially of the gingival mucosa, scars, and skin creases), vitiligo, postural hypotension, abdominal pain, nausea and vomiting, diarrhea, constipation, myalgias, and arthralgias. The most specific sign of

Acute adrenal crisis is characterized by rapid onset of hypotension, bradycardia, fever, hypoglycemia, and a progressive deterioration in mental status. Abdominal pain and diarrhea may be present.

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btw can pituitary tumor can explain this?
( i guess this can't do diarrhea and constipation)

can anybody make me clear?
thanks in advance.



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  #6

It is A, due to adrenal mets leading to adrenal insufficiency







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