Van Damm
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A 53 yo man with a long history of smoking presents to a physician with complaints of fatigue, anorexia, weight loss, cough, hemoptysis. Bronchoscopy: mass on one bronchus, on biopsy: small, round cells with dark nuclei, scant cytoplasm, fine granular nuclear chromatin, indistinct nucleoli.These cells would most likely stain positivile with an immunohistochemical stain for which of the following ?
A) Hemoglobin
B) CA-19-9
C) Alpha fetoprotein
D) Neuron specific enolase
E) Hematocrit
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| robin082006
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B?
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| spjokes
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This is a small cell carcinoma lung
ANS: D. neuron specific enolase
Positive stains for small cell lung cancer: pan-keratin (100%, dot like pattern), CK-BB (91%), TTF1 (89%), histamine decarboxylase (78%, Mod Path 2003;16:72), neuron specific enolase (77%), CD117 (75%, 50% after chemotherapy), chromogranin (58%, may be weak), synaptophysin (57%), calretinin (49%)
http://www.pathologyoutlines.com/lungtumor.html#s...
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| Van Damm
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The answer is : D
Good job spjokes .
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| tolito
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spjokes, are you a pathologist???
CA 19-9 is for pancreatic CA.
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| spjokes
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yes tolito I am a histopathologist
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