asmi
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How do you differentiate PML ( caused by jc virus) from CMV considering them with regards to pt's with AID'S ?
plz stress on :
* clinical features
* diagnosis
thanks in advance 
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| Idiopathic
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I am not so sure that you can. At the PML stage, your everyday, garden-variety AIDS Px is pretty much screwed, and it looks like a serious encephalopathy, much like your CMV encephalopathy would. The definitive Dx (which apparently isnt even all that definitive) is brain biopsy. For someone to do that, they have to assume they can fix it...I dunno how I would differentiate.
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| asmi
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There was a Q in q bank..
A pt with AIDS who developed seizures....Investigation showed demyelination of nerves and intranuclear inclusion bodies...Among the given choices were CMV and JC virus. I thought the answer is CMV(since its more common with AIDS).But the answer was JC virus.
Thats why I wanted my friends (all DOC'S) to know this issue.
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| Idiopathic
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Found the answer. When you see dyelination disease in AIDS, you consider PML caused by JC first. CMV is very disseminated and is not responsible for demyelination as primary pathogenesis.
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| asmi
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thanks
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