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Previous Topic | Next Topic  diuretic to treat diabetes insipidus???? 




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Author5 Posts
  #1

can anyone explain.........whats the rationalization behind using thiazide diuretic to treat diabetes insipidus(ADH resistance)?

  #2

INTRAVASUCLAR volume contraction increases ADH secretion,overriding the effect of hyposmolarity

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  #3

thanks mjl......
but ,how does that help the patient as the increase in ADH wont do anything coz in this condition the collecting ducts are unresponsive to ADH....... :?

  #4

you are right -HYDRATION (ADH does nothing)

**Thiazide decreases urine flow by inhibiting sodium reabsorption in distal tubule**This lowers free water production and, by causing extracelular volume contraction,increases proximal salt and water reabsorption,reducing delivery to the distal nephron. :idea:

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  #5

:idea:
thanks mjl!!! grin









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