DrVirgo
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A family has a rare genetic disease involving defective adhesion of leukocytes. Affected family members suffer from recurrent bacterial and fungal infections and impaired wound healing. The molecular basis of this disease is related to deficient expression of which of the following?
A. Adenosine deaminase
B. IgA
C. IgG
D. Integrins
E. Neutrophil cytochrome B
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| robin082006
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D
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| DrVirgo
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yes. why?
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| robin082006
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Leukocyte adhesion deficiency, lack CD18, a part of integrins
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| Cedrick
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and part of healing
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| DrVirgo
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D. is right...
The defective molecules in this condition is the beta2 integrin... aka CD11/CD18 family of glycoproteins...
These function both in the adhesion of leukocytes to other cells and in the phagocytosis of complement-coated material.
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D
It's in Kaplan Microbiology-Immunology
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