DrVirgo
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What is the difference between the two?
Can anyone explain in their own words and give clinical examples of both?
Thanks. 
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| study_ing
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An Arthus reaction is a LOCALIZED immune complex reaction.
For example, if an individual has been sensitized to antigens in the tetanus toxoid vaccine because of repeated vaccinations and if that individual were vaccinated again, at the injection site there would be large amounts of antigen with which the antibody could complex, causing a localized inflammatory response, neutrophil infiltration, and tissue necrosis.
Serum sickness is a systemic Arthus reaction in which the antibody-antigen complexes circulate and lodge in many different tissues.
Serum sickness can develop from prolonged exposure to an antigen that provides enough time for an antibody response and the formation of many immune complexes. .
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