DrVirgo
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What type of Hypersensitivity are the following:
Guillian-Barre Syndrome
Hashimoto's Thyroiditis
Multiple Sclerosis
Type I DM
Peripheral Neuritis
I, II, III, or IV???
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| study_ing
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hashimotos and, type i and MS wud be type II i think
dont know abt other two
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| muzammil
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i think that gb syndrome and type 1 idm and peripheral neuritis is type 2
cant say about others
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| robin082006
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Hahaha Virgo why didn't you add contact dermatitis in the list?
all are type IV hypersensitivity.
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| DrVirgo
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Robin is RIGHT!  ALL of these are type IV!
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| Cedrick
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I see we are all tired !
Yes IV
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| khorshid
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Why is hashimoto type IV when Ab is playing a role in it? I mean doesn't it say that Abs and complements play no role in DTH? please somebody explain it for me.
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| study_ing
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same confusion i have...initially my reflex was AB--> cross out type IV hypersensitivity..however ive realised that u classify a disease acording to the MAJOR mechanism of damge..in hashimoto's Ab are formed but the major terrorist is the T cell reacting against a specific ag.
in retrospect i think of another simple example...how do u deal with viruses? T cell mediated immunity, right...but antibodies against them may be found.
in DM and MS, antiboides are also found. ..but type 4 aytotoxicity plays a role.
thank u Dr virgo for posting this question and khorshid, i read javetz and kaplan immunolgy to make the above assumptions..hope im right
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| tolito
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i just go by the fact that type 4 are cell mediated by cytotoxic T cells. while mantoux reaction is helper T cel and macrophage mediated.
GVH is also cytotoxic T cell mediated.
to my knowledge no Ab, no complement are involved in type IV reactions.
some of these conditons actually have mixed components to them for eg hashimoto's has both ADCC and cell mediated ( infiltrated by B and T lymphocytes and plasma cells)
type 1 DM also antibody component to it ie type II ( anti islet cell ab, anti insulin ab) and type 4 ( islet cells are infiltrated by B and T cells) and are destroyed by cytotoxic T cells.
latex sensitivity has type 1 as well as type 4 depending on the onset of reaction.
SLE has both type 2 and 3.
i think the better way to look at these condition that have mixed reactions woudl be in the context of the question and not to just learn them as absolutes. remember GOLJAN.
Edited by tolito on 07/19/06 - 12:51 AM
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| khorshid
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study-ing and tolito thanx for the explanations
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| Palaniappan
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Hi guys..
What hypersensitivity is
*Acute rheumatic fever
* Post-streptococcal glomerulonephritis?
*Good Pasture's syndrome
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| ManuNastai
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RF type 2
PSGN type 3
GP type 2
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| Palaniappan
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Yes.Post-streptococcal Rheumatic fever is caused by molecular mimicry and hence it is due to antibody reaction to the antigen present inside the tissues or cells.-hENCE TYPE 2.where as PSGN the antigen-antibody complex gets traspped in the basement membrane of the kidney after circulation-hence type 3.
Do correct me if I am wrong
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