Cedrick
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After activation neutrophils demostrate an increased tendency to migrate out of blood vessels and into the extravascular compartment
Which of the following is the most likely cause ?
a.- altered expression of adhesion molecules
b.-heightened phagocytic ability
c.-increased synthesis of lysosomal enzymes
d.-release of interleukin -1{IL-1}
e.-upregualted synthesis of Fc receptors
I know that this has been talked about before but the answers was not clear
Thanks
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| Cedrick
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?
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| study_ing
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im confused btw a and D
b and c wud not be the ans as they are not involved with the process of migratiion.
are they asking about adhesion or chemotaxis here?
Edited by study_ing on 07/15/06 - 09:06 PM
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| Cedrick
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preveiuly the answers was
A,
I put down D,just to check with the forum
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| Cedrick
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| raves
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i would go with A
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| pallav
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IL 1 is the right answer
i guessssssssss
please tell the rt answer quickly
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| muzammil
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i think its a
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| muzammil
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the chemotactic factors to cause neutro movement out of cell are
IL 8
fbrinopeptide
complement product
formylmethoyl peptide produced from bacteria
refrence kaplan notes 2005 immuno chapter 3 or 4
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| muzammil
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in lAD its a adhension molecule deficiency ie itegrin which causing all the problem and not letting leukocytes outin tissues while in these patients the level of leukocytes is normal or above normal in blood
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| MRMAVERICK
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a
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| robin082006
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aaaaaaaa
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| Cedrick
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A as before
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| tolito
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this is one baaaad question. i will go with A.
the question is asking about chemotaxis. il 1 does not function there per se. it is il 8. after activation by chemokines, the adhesion molecules are modulated to increase their affinity for the corrresponding molecules on the endothelium.
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| vamsi2004
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IL-1 upregulates the adhesion molecules of endothelial cells..
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| MRMAVERICK
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yup-il 1 and tnf are reponsible for upregulation af adhesion molecules on endothelial cells-
it is the expression of integrins on neutrophils by ltb4 and c5a that mak them sticky and aid in thier migration
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| docarchana
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Both A and D appear to be right. i think its better to go with A.
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| poli
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I will go with B because neutrophils do have phagocytic action, I don't understand A because we don't have defect in adhesion molecules here if the adhesion molecules were defective we would have LAD.
Remember neutrophils do the homing process leaving the blood to go to the site of inflammation using ahesion molecules LFA-1 OR Mac-1 with the endothelial cell adhesion molecule ICAM-1 OR ICAM-2
ANY WAY CORRECT ME IF I AM WRONG
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| proctalgia
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increased tendency to migrate ------> collagenase from neutrophils destroy Type IV collagen in the basement membrane to fascilitate migration of neutrophils
Can C be correct?
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| sjain4
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It is A all the way.
We're basically talking about extravasating, the rolling, adhesion sequence for phagocytes such as neutrophils leaving the blood vessels. Page 42 of the '07 kaplan notes for immunology.
"The first step in the acute inflammatorry response is activation of the vascular endothelium in the breached epithelial barrier. Bytokines and other inflammatory mediators released in the area as a result of dissue damage induce expression of selectin-type adhesion molecules on the endothelial cells. Neutrophils are usually the first cell to bind to the inflamed endothelium and extravasate into the tissues..."
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| po
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A looks alright
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