Cedrick
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Methimazole is effective for treatment of Graves disease because it has which of the following mechanism of actions ?
a.-blockade of binding of thyroxine to its receptors
b.-decreased uptake of iodide by thyroid gland
c.-inhibition of thyroidal peroxidase activity
d.-prevention of the proteolysis
e.-stimulation of production of serum thyroid binding globulin
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| drpkaur
Forum Guru
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C..
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| MHP
Forum Senior
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I think is B. I am not sure
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| Cedrick
Forum Fanatic
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B.-decrease uptake of iodide by the thyroid gland
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| MHP
Forum Senior
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perfect!!
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| reet
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METHIMAZOLE---thyroid HORMONE RECEPTOR ATAGONIST..??
-IODINE uptake ---radioactive I- uptake incresed to desroy the gland)
I- to I * (thyroid peroxidase inhibiters ) -DRUGS ACTING -propylthiouracil and methimazole.
Proteolysis( release of hormones)--- Inhibited by IODIDE salts.
PERIPHERAL conversion T4 to T3 -- inhibited by IPODATE, beta blockers.
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| vamsi2004
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so the ans is C. good stuff reet
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| docswapna
Forum Senior
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yes its C. leopard, has sometime back posted a very good link on this.
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| lightray
Forum Newbie
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Which thiomamide is safer to use in pregnancy- Propylthiouracil or Methimazole...and why?
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