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01/16/04 - 01:43 PM       #1

what is tyramine and what is the significant in ANS pharm?

asmi
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01/16/04 - 03:38 PM       #2

Tyramine is a normal byproduct of tyrosine metabolism.Its an indirect acting adrenergic agonist.

Sources: fermented foods...ripe cheese ,wine etc.

Action: it can enter the nerve terminals and displace stored norepinephrine--->catecholamines acts on adrenoceptors.

Implicated in hypertensive crisis in pt's on MAOI.









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