ord
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mutations in the cystic fibrosis transmembrane conductance regulator(CFTR) protein alter which of the following ion transport mechanisms?
a)Ca2+ activated Cl-secretion
b)Ca2+ activated Cl-uptake
C)cyclic Amp(cAMP) stimulated Cl-secretion
d)cAMP stimulated Na+secretion
e)cAMP stimulated Na+uptake
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| ord
Forum Junior
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Is it A?
Edited by ord on 07/01/06 - 01:45 PM
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| alpha12
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I'd go with C, but not sure. I guess the second messenger should be the same than secretin (cAMP)
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| robin082006
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THIS HAS BEEN DISCUSSED
SOME AGRED WITH C, SOME WITH D
I GO WITH C
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| Cedrick
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C
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| waqastariq
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it's C people 
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| waqastariq
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lemme find some links for it then.. 
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| waqastariq
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http://humrep.oxfordjournals.org/cgi/content/abst...
http://www.bioscience.org/knockout/cftr.htm
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| zzzz
Forum Elite
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i think it was in kaplan d bank & it is c .
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| tolito
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C. cl secretion occurs via camp activation of protein kinase A. prot kin A phosphorylates CFTR resulting in opening of cl channel.... source, robbins.
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| dericanthony
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very resorceful wasaspas
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| what to do
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ans C
there is gene mutation in long arm of chromosome 7 (7q21.3 --> 7q22.1) the commonest abnormality is a specific deletion in position 508 in the aminoacid sequence which results in defective CFTR . it is a Cl channel. the mutation alters the secondary and tertiary structure of the protein, leading to the failure of the opening of the of the chloride channel in response to elevated cAMP in epithelial cells. this results the decreased excreation of Cl and increased reabsorption of Na.
30% ashkenazi, 50% european, 70% USA
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saif
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| what to do
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ans C
there is gene mutation in long arm of chromosome 7 (7q21.3 --> 7q22.1) the commonest abnormality is a specific deletion in position 508 in the aminoacid sequence which results in defective CFTR . it is a Cl channel. the mutation alters the secondary and tertiary structure of the protein, leading to the failure of the opening of the of the chloride channel in response to elevated cAMP in epithelial cells. this results the decreased excreation of Cl and increased reabsorption of Na.
30% ashkenazi, 50% european, 70% USA
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saif
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| Ancylostoma
Forum Guru
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C is right, it cant be d because normall there is secretion of cloride and reabsorbion of na. The clhorid keeps the water in the lumen. When there is a problem in secretion of chloride, there is nothing to keep the water on that side. the sodium is reabsorbed as it is normall, but because of lask of chloride water goes with it leading to thick secretions.
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