Peterparker
Forum Senior
Topics: 28
Posts: 60
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other then thrombosis, what are the other side effects of cox-2 inhibitors?? Any explanation to why these side effects happen???
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| Peterparker
Forum Senior
Topics: 28
Posts: 60
|
do NSAIDS in general also causes thrombosis??? And why???
We all know of the antiplatelet effects of aspirin in reducing thrombosis and embolism, isn't aspirin related to the NSAIDS family???
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| Peterparker
Forum Senior
Topics: 28
Posts: 60
|
-GI side effects due mainly to inhibition of cox-1
-anti-inflam therapeutic effect due mainly to inhibition of cox-2
THUS COX-2 is out in the market.
some cox-2 inhibitors proven to increase risks of thrombosis and embolism
High doses of some NSAIDs also increased risks of thrombosis and embolism mediated by inhibition of cox-2
Antiplatelet effect of aspirin due largely to inhibition of cox-1 and there is less effect on inhibition of cox-2, so aspirin does not lead to increase risk of thrombosis???
In selecting the drugs, need to balance the risk of cox-1 inhibitors- in causing GI problems vs the risk of cox-2 inhibitors- in causing thrombosis
Pls correct me if I am wrong
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