mjl1717
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This important, prototype, H1 antagonist med is NOT used for:
a)sedative qualities
b)actue dystonia
c)tremor & rigidity
d)bradykinesia
e)rhinorhea
f)pruritis
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| drkirti79
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b???
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| motivated2
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Diphenhydramine are antihistmines w/ anticholinergic effects so it's not advisable for tremor & rigidity.
Ans. C
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| drpkaur
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Diphenhydramine hydrochloride (trade name Benadryl®, as produced by Pfizer or Dimedrol outside the US) is an over-the-counter (OTC) antihistamine and sedative. It is also given in conjunction with typical antipsychotics to prevent akathisia. It is a member of the ethanolamine class of antihistaminergic agents.Indicated for:
Antihistaminic Motion sickness
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| drpkaur
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sorry for interrruption
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| drpkaur
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Sedative Akathisia
Other uses:
Halting allergic reactions, controlling extrapyramidal sideffects induced by anticonvulsants...
Extrapyramidal side effects (EPS) are the various movement disorders suffered as a result of taking dopamine antagonists, usually antipsychotic (neuroleptic) drugs, which are often used to control psychosis, especially schizophrenia. Other antidopaminergic drugs like the antiemetic metoclopramide or the tricyclic antidepressant amoxapine can also cause extrapyramidal side effects.
Common EPS are akathisia (restlessness), dystonia (muscular spasms of neck - torticollis, eyes - oculogyric crisis, tongue, or jaw; more frequent in children), drug-induced parkinsonism (muscle stiffness, shuffling gait, drooling, tremor; more frequent in adults and the elderly), and tardive dyskinesia (involuntary, irregular muscle movements, usually in the face).
Commonly used medications for EPS are benztropine (Cogentin), diphenhydramine (Benadryl), and trihexyphenidyl (Artane).
bradykinesia means slow movement ,it occurs in parkinson's disease...is it C ..i am confused..
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| mjl1717
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drpkaur -you have no reason to be confuse!! you were quite complete and have the correct answer with your monologue {with all due respect} and/ or your deductive reasoning. since learning can be conscious as well as extemporaneous ill focus on some of your highlights..
For usmle they will ask only generic names. 2nd generation antihistamines would be loratidine(Claritan) and terfenadine {Allegra}, they dont cause the drowsiness with Q.D. dosing.
meclizine also a first generation antihistamine along with{ scopolamine, glycopyrolate and pilocarpine-excuse me this is a completely different category-anticholinergic} is popular for benign positional vertigo and motion sickness. An old lady with vertgo may come to you and say the "tiny blue pills" thats meclizine" and once you I.D. that tiny blue pill she is greatly relieved. Also in reference to "Benedryl " as we both know its an old dinosaur that is good for putting people to sleep! { i believe it comes in 25mg. increments} As far as I know dystonia and tardive dyskinesia are lesser and greater forms of the same thing. I didnt think the diphenhydramine category was used for EPS till recently but it does not stop or treat bradykinesia as you deduced. As you said Trihexphenydl, Congentin and diphenhydramine are the big 3 used for EPS or in Parkinson since in Parkinson they attempt to increase dopamine but diminish cholinergic affects. Good communication..
Edited by mjl1717 on 07/01/06 - 03:20 AM
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| disha
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YES ITS C
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| shumaker
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D
diphenhydramine can be used in parkinsons to treat tremor and rigidity but it doesnt help to improve bradykinesia.correct me if im wrong
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| MHP
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Shumaker you are right the answer is D.
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